The economy of Kei Mouth revolves largely around tourism due to its location at the southern entrance to the erstwhile Transkei region. Whilst many of the residents are retirees, a large portion of homes are holiday homes owned by families from the interior. There are several accommodation establishments, a municipal campsite, two restaurants and bars, two small supermarkets and a service station.

The Strandloper hiking trail is a 4 day, 3 night backpacking hike starting at Kei Mouth and ending in Gonubie (R400 per person for the trail)

Sundowner hotel trail (slackpacking) Seagulls Beach Hotel to Inkwenkwezi Private Game Reserve - 5 nights (8 - 12 hikers R3 800 per person). Inclusive of transfer to start, daily lunch packs and full board.

Kei Mouth is one of the undiscovered jewels of South Africa. Kei Mouth is particularly popular with anglers, since it has some excellent fishing grounds, both at the coast and at the mouth of the Kei River, which is navigable for some kilometres upstream. For those feeling a little more adventurous, there is always deep sea fishing. or river rafting down the rapids. Visitors can cross the river by pontoon-ferry and the opposite bank offers a number of exciting 4x4 trails. Kei Mouth also boasts an 18-hole golf course complete with welcoming clubhouse and a fantastic view of the ocean.